abstract：BACKGROUND:Since the introduction of biologic treatment in rheumatoid arthritis (RA), disease activity and treatment modalities have changed substantially. The current provision and developments in recent years are analyzed with annual data from the National Database of the Collaborative Arthritis Centers in Germany. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Albrecht K,Huscher D,Eidner T,Kleinert S,Späthling-Mestekemper S,Bischoff S,Zink A

更新日期：2017-02-01 00:00:00

abstract：:Many rheumatological diseases are either caused by specific known proteins, such as antibodies or mediated by a plethora of cytokines. Both the unspecific immunosuppressive therapy and the specific action of biologics usually require time to be effective; therefore, extracorporeal forms of treatment are increasingly b...

journal_title：Zeitschrift fur Rheumatologie

authors： Boser M,Kielstein JT

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease with a prevalence of up to 1 % in the adult population. OBJECTIVE:This study describes the prevalence of RA diagnoses in outpatient health insurance claims data, based on different case definitions and stratified by age, sex and...

journal_title：Zeitschrift fur Rheumatologie

authors： Hense S,Luque Ramos A,Callhoff J,Albrecht K,Zink A,Hoffmann F

更新日期：2016-10-01 00:00:00

abstract：:Childhood onset rheumatic and musculoskeletal diseases often continue into adulthood. These diseases are associated with a high risk of permanent disability and impairment in the quality of life of people affected. Adolescence and young adulthood represent a particular risk phase for an unfavorable long-term outcome. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Minden K,Schalm S

更新日期：2016-08-01 00:00:00

abstract：:In recent years the great progress in knowledge on bone cell biology has allowed identification of molecular structures that can be targeted with pinpoint precision (druggable targets). Osteoclasts are regulated via the RANK-RANK-ligand (RANKL) signaling pathway and osteoblasts via the Wnt signaling pathway, both of w...

journal_title：Zeitschrift fur Rheumatologie

authors： Knauerhase A,Willenberg HS

更新日期：2016-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) results from loss of immunological tolerance. Regulatory T‑cells (Treg) are major gatekeepers of peripheral tolerance by suppression of autoreactive lymphocytes. Defects in Treg function are therefore possible pathogenetic mechanisms of SLE. Despite this fact published work about num...

journal_title：Zeitschrift fur Rheumatologie

authors： Ohl K,Tenbrock K

更新日期：2016-04-01 00:00:00

abstract：:Rheumatoid vasculitis usually occurs on the background of seropositive rheumatoid arthritis, although in rare cases the patients can be seronegative. We report a woman with seronegative rheumatoid arthritis with rheumatoid vasculitis who developed toxic epidermal necrolysis involving most of her body surface area, whi...

journal_title：Zeitschrift fur Rheumatologie

authors： Chowdhury AC,Misra DP,Patro PS,Agarwal V

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:Only insufficient data are available regarding the question whether treatment with immunosuppressants or biologicals is feasible and safe in patients with a history of malignancy. METHOD:Literature search via PubMed, EULAR abstracts and ACR abstracts from 2013 to 2015. RESULTS:The Société Francaise de Rh...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmalzing M,Strangfeld A,Tony HP

更新日期：2016-02-01 00:00:00

abstract：:The duration and severity of rheumatic diseases of the shoulder correlate with symptom frequency, structural changes and associated functional limitations. The multifactorial character of the underlying rheumatic disease requires a multimodal therapeutic concept including interaction of surgical and non-surgical disci...

journal_title：Zeitschrift fur Rheumatologie

authors： Heers G,Grifka J,Springorum HR,Craiovan B,Anders S

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:The treatment strategies for osteoarthritis (OA) are well known from numerous studies. One of the challenges is long-term patient compliance to the recommended therapies without supervision. OBJECTIVE:To examine the ability of salutogenic concepts to improve rehabilitative management of OA. MATERIALS AND M...

journal_title：Zeitschrift fur Rheumatologie

authors： Benz T,Aeschlimann A,Angst F

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease affecting a broad range of different organ systems and, hence, presenting with multiple symptomatic domains, which considerably reduces the quality of life of patients. Within the last decade the prognosis of the disease has been...

journal_title：Zeitschrift fur Rheumatologie

authors： Schneider M,Haupt M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The goal of the present study was to investigate the osteogenic potential of ligament fibroblasts from patients with ankylosing spondylitis (AS). MATERIALS AND METHODS:Ligament fibroblasts were isolated from tissues harvested from AS patients and patients with aseptic necrosis of the femoral head (ANFH) who...

journal_title：Zeitschrift fur Rheumatologie

authors： Yang M,Yuan H,Miao M,Xu W

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities. METHODS:We conducted a literature search using th...

journal_title：Zeitschrift fur Rheumatologie

authors： Lee YH,Bae SC,Kim JH,Seo YH,Choi SJ,Ji JD,Song GG

更新日期：2015-05-01 00:00:00

abstract：:Interstitial nephritis is responsible for about 12 % of end-stage renal disease in Germany. It comprises an etiologically heterogenous group of inflammatory renal disorders which primarily affect the renal interstitium and tubuli. Drugs, predominantly antibiotics, nonsteroidal anti-inflammatory drugs and proton pump i...

journal_title：Zeitschrift fur Rheumatologie

authors： Korsten P,Müller GA

更新日期：2015-05-01 00:00:00

abstract：:Large data bases and the projects arising from them have led to a much improved understanding of systemic sclerosis over the last decade. Serology has developed further so that more autoantibodies are available for routine testing. Capillary microscopy has become standard and relevant progress has also been made in th...

journal_title：Zeitschrift fur Rheumatologie

authors： Aringer M,Müller-Ladner U,Burkhardt H,Distler JH,Distler O,Graninger WB,Günther C,Hunzelmann N,Kiener H,Sticherling M,Sunderkötter C,Walker UA,Riemekasten G

更新日期：2015-03-01 00:00:00

abstract：:Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium size arteries that may affect various organs. The clinical appearance is very variable. The most common manifestations are of the skin, the peripheral nervous system presenting as mononeuritis multiplex and the mesenteric and renal blood vessels due to t...

journal_title：Zeitschrift fur Rheumatologie

authors： Schirmer JH,Holl-Ulrich K,Moosig F

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis is found in approximately 2 % of the total population in Europe and the peak incidence of the disease is during the fourth and fifth decades of life. In approximately 15 % the first symptoms of the disease occur at the level of the foot and ankle. If the early stage-dependent therapy wit...

journal_title：Zeitschrift fur Rheumatologie

authors： Thomas M,Jordan M

更新日期：2014-11-01 00:00:00

abstract：:The SAPHO syndrome, an acronym for synovitis, acne, pustulosis, hyperostosis and osteitis, is a rare disease which affects bones, joints and the skin. The main osteoarticular features are hyperostosis and osteitis. Osteoarticular symptoms predominantly occur on the anterior chest wall but the spine and the peripheral ...

journal_title：Zeitschrift fur Rheumatologie

authors： Heldmann F,Kiltz U,Baraliakos X,Braun J

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Sex-specific differences in the prevalence and severity of immune disorders are well-known phenomena; however, it is only recently that we have begun to understand the possible causes of such differences. MATERIAL AND METHODS:A literature search on this topic was carried out and the results are summarized. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Riemekasten G,Siegert E

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Sport is becoming increasingly more important in our society. Due to the changing age spectrum with a greater number of elderly and substantially more active people, an increasing number of people with underlying orthopedic diseases are becoming interested in participating in sport. MATERIAL AND METHODS:Thi...

journal_title：Zeitschrift fur Rheumatologie

authors： Proschek D,Rehart S

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Patients with an inflammatory disease have an elevated risk for periprosthetic joint infections due to impairment of the immune system caused by the disease itself in combination with disease-modifying antirheumatic drugs (DMARD). These infections can cause life-threatening sepsis. Unfortunately recommendati...

journal_title：Zeitschrift fur Rheumatologie

authors： Illgner U,Uekötter A,Bause L

更新日期：2014-06-01 00:00:00

abstract：:In general, the risk of serious infections increases with age, mainly explained by immunosenescence and accumulation of comorbidities. Those patients with rheumatoid arthritis who are of advanced age and require treatment with immunosuppressive agents are at particular risk to develop an infectious disease. Actual req...

journal_title：Zeitschrift fur Rheumatologie

authors： Kneitz C,Strangfeld A,Krüger K

更新日期：2014-04-01 00:00:00

abstract：:Mainly due to the general demographic changes and decreasing mortality in rheumatic diseases based on therapeutic progress, the proportion of older patients treated by rheumatologists is growing. Drug treatment in the elderly, however, harbors certain risks including age-specific pharmacokinetic features and high rate...

journal_title：Zeitschrift fur Rheumatologie

authors： Krüger K,Strangfeld A,Kneitz C

更新日期：2014-04-01 00:00:00

abstract：:Health services research in rheumatology investigates the healthcare needs, the quality of care and trends in healthcare for patients with musculoskeletal disorders. Using rheumatoid arthritis (RA) as an example, key results of health services research during the last 25 years are summarized. There are currently appro...

journal_title：Zeitschrift fur Rheumatologie

authors： Zink A

更新日期：2014-03-01 00:00:00

abstract：:A female patient developed systemic rash, lung edema, electrocardiogram (ECG) abnormalities and fulminant hepatitis with partial liver failure 4 weeks after the start of sulfasalazine treatment. Peripheral T-cell activation, a positive PCR test for human herpesvirus (HHV) 6 as well as eosinophilia in bronchial lavage ...

journal_title：Zeitschrift fur Rheumatologie

authors： Pirklbauer M,Gruber J

更新日期：2014-03-01 00:00:00

abstract：:Recent Deutsche Gesellschaft für Rheumatologie (DGRh, German Society of Rheumatology) guidelines emphasized the significance of coordinated multidisciplinary care and rehabilitation of patients with inflammatory rheumatic diseases. Nationwide data from the German pension insurance funds showed that inpatient rehabilit...

journal_title：Zeitschrift fur Rheumatologie

authors： Mau W,Beyer W,Ehlebracht-König I,Engel JM,Genth E,Jäckel WH,Lange U,Thiele K

更新日期：2014-03-01 00:00:00

abstract：:Reactive arthritis is an inflammatory joint disease induced by a preceding, sometimes asymptomatic bacterial infection outside the joints. With an estimated prevalence of 40/100,000 inhabitants, the disease primarily affects adults between the ages of 20 and 40 years. The clinical presentation is typically characteriz...

journal_title：Zeitschrift fur Rheumatologie

authors： Brzank M,Wollenhaupt J

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Data with respect to safety and therapeutic efficacy for the combination of biological DMARDs is scarce and inhomogeneous in order to make final conclusions. To this end, data to biologic combinations is disappointing due to relatively low therapeutic efficacy and partially enhanced rates of severe infecti...

journal_title：Zeitschrift fur Rheumatologie

authors： Härle P

更新日期：2013-11-01 00:00:00

abstract：:When patents expire, usually after 10 years in Germany, generic medicines routinely enter the market in place of conventional medications leading to significant reductions in prices. Currently the first biologicals are approaching patent expiry. Because of the biochemical complexities truly identical imitators are unr...

journal_title：Zeitschrift fur Rheumatologie

authors： Aringer M,Dörner T

更新日期：2013-11-01 00:00:00

abstract：:This review presents an overview of the range of imaging modalities used in the diagnostic evaluation of patients with psoriatic arthritis (PsA). Conventional radiography is used to detect structural changes of the joints and tendon attachments. These changes occur late in the course of PsA hence conventional radiogra...

journal_title：Zeitschrift fur Rheumatologie

authors： Hermann KG,Ohrndorf S,Werner SG,Finzel S,Backhaus M

更新日期：2013-10-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) represents the most common clinically relevant form of primary immunodeficiency. This heterogeneous antibody deficiency syndrome is characterized not only by susceptibility to bacterial respiratory tract infections but displays additional signs of immune dysregulation, such as a...

journal_title：Zeitschrift fur Rheumatologie

authors： Warnatz K,Goldacker S

更新日期：2013-09-01 00:00:00

abstract：:An appropriate treatment of elderly rheumatic patients implements comprehensive diagnostics and exclusion diagnostics of e.g. coronary heart disease, osteoporosis, renal failure, diabetes mellitus type 2 and thyroid gland dysfunction. Furthermore, the complex disease situation might require the integration of other fa...

journal_title：Zeitschrift fur Rheumatologie

authors： Lakomek HJ,Brabant T,Lakomek M,Lüttje D

更新日期：2013-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is associated with a shortened life expectancy. Most premature deaths are caused by cardiovascular (CV) events; therefore it is of importance to consider the increased CV risk when treating RA patients. Traditional CV risk factors cannot fully explain the increased risk but the common underst...

journal_title：Zeitschrift fur Rheumatologie

authors： Pieringer H,Hoppe UC

更新日期：2013-05-01 00:00:00

abstract：:In rheumatologic diseases magnet resonance imaging (MRI) is capable of depicting early inflammatory changes which are frequently missed by other imaging modalities. New MRI protocols and hardware, primarily whole-body MRI and low-field extremity MRI facilitate the use of MRI in rheumatology patients. The increasing nu...

journal_title：Zeitschrift fur Rheumatologie

authors： Buchbender C,Schneider M,Ostendorf B

更新日期：2013-03-01 00:00:00

abstract：:Personalized healthcare tries to predict the effectiveness and safety in individual therapeutic approaches by defining individual patient characteristics (biomarkers), while stratification uses diagnostic patterns for groups of patients for prediction of therapeutic response with less adverse reactions caused by the d...

journal_title：Zeitschrift fur Rheumatologie

authors： Behrens F,Köhm M

更新日期：2013-02-01 00:00:00

abstract：:Up to now stratified therapy concepts have not played an important role in the treatment of patients with rheumatoid arthritis; however, a high heterogeneity regarding the effectiveness of therapies and occurrence of side effects in patients with the same indications provokes research efforts aiming at identifying and...

journal_title：Zeitschrift fur Rheumatologie

authors： Frank M,Mittendorf T

更新日期：2013-02-01 00:00:00

abstract：:Biomarkers form the basis for patient stratification and the development of individualized treatment strategies. As the understanding of the pathophysiological processes underlying rheumatic diseases increases, novel biomarkers will become available and established markers can be used more efficiently. Autoantibodies ...

journal_title：Zeitschrift fur Rheumatologie

authors： Scherer HU,Burmester GR,Häupl T

更新日期：2013-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) represents an autoimmune disease affecting mostly joints, in particular small finger and toe joints. In addition RA can show extra-articular manifestations in many organs. Information on the frequency of extra-articular manifestations (EAMs) in RA varies greatly in different publications from...

journal_title：Zeitschrift fur Rheumatologie

authors： Baerwald C,Kneitz C,Bach M,Licht M

更新日期：2012-12-01 00:00:00

abstract：:Following the EULAR recommendations published in 2010 German guidelines for the medical treatment of rheumatoid arthritis were developed based on an update of the systematic literature search and expert consensus. Methotrexate is the standard treatment option at the time of diagnosis, preferably in combination with lo...

journal_title：Zeitschrift fur Rheumatologie

authors： Krüger K,Wollenhaupt J,Albrecht K,Alten R,Backhaus M,Baerwald C,Bolten W,Braun J,Burkhardt H,Burmester G,Gaubitz M,Gause A,Gromnica-Ihle E,Kellner H,Kuipers J,Krause A,Lorenz HM,Manger B,Nüßlein H,Pott HG,Rubbert-

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Scleromyxedema is a rare connective tissue disease that may affect numerous internal organs in addition to the skin. The disease is almost exclusively associated with monoclonal gammopathy. MATERIAL AND METHODS:This retrospective study summarizes the clinical characteristics of four patients with scleromyxe...

journal_title：Zeitschrift fur Rheumatologie

authors： Kreuter A,Stücker M,Kolios AG,Altmeyer P,Möllenhoff K

更新日期：2012-08-01 00:00:00